Unit 3 – Medical and Pharmaceutical Engineering: Non-Destructive Biomedical and Pharmaceutical Research Centre specialises in multi-particulate system design and development from the perspectives of material science, formulation strategy, processing and equipment design. The multi-particulate system, from nano, micro to millimetre scale, fits the requirements of dosage form for use to personalise one’s therapy. To enable the delivery system meeting the required pharmacokinetics and pharmacodynamics performances of the drugs, the multi-particulate system is subjected to physicochemical modification where targeting ligands, penetration enhancer and other functional excipients are introduced. Its use is combined with novel active technology or administration approach as a function of the route of drug administration.

With reference to skin drug delivery, Unit 3 – Medical and Pharmaceutical Engineering: Non-Destructive Biomedical and Pharmaceutical Research Centre represents the first entity worldwide that investigates the potential of precision microwave to facilitate the nanoparticulate drugs to overcome the skin barrier, with the aim to promote skin drug retention and/or systemic drug permeation for the treatment of melanoma and diabetes. Microwave is regarded as a skin penetration enhancer where electrical shock, unnecessary physical disposal, high risks of skin burn, edema and irritation are not found, unlike iontophoresis, electroporation, microneedles, sonophoresis and laser methods.  

In the case of oral drug delivery, the global first colon-specific coatless pellets, in vivo instead of fluid - bed coated spheroids, and nanoparticles-in microagglomerate systems are designed for tissue- and cell-specific delivery of cancer therapeutics and related actives. These designs translate to ease of dosage form manufacturing industrially, reduction of delivery performance irreproducibility and enabling of nanoparticulate drugs to survive the harsh gastrointestinal tract without signs of premature release in the upper gut. The nanoparticles-on-microparticles delivery system is developed to carry the nanoparticulate drugs into deep and peripheral lungs for cancer and infection control. The current system allows reformulation of nanoparticulate drugs without affecting their nanoscale that is critical to biological actions.


The unit is built on the concept of outcome-based research, incorporating academic, business and personal ethics to meet the rising standard of goals and challenges.


The research involves active participation of both local and overseas researchers. The latter constitutes of scientists from Parma University, Pavia University, Camerino University, Perugia University, Italy; Northwestern University, Switzerland; South Brittany University, France; Jadavpur University, Calcutta University, Mahatma Gandhi University, Adamas University, NIPER, India; National University of Singapore, Singapore; Yangzhou University, China; Chulalongkorn University, Thailand; Brunei University of Darussalam, Brunei; Witwatersrand University, South Africa; TexasTech University Health Science Centre, USA, as well as The University of Western Australia, Australia.

Research Direction

The research direction mainly focuses on:

1. design of transdermal drug delivery system or equivalent of which represents a mode of drug administration without the patients suffering in pain owing to the destruction of skin by injection needle.

2. design of pellets, microparticles and nanoparticles for small molecule drugs, protein drugs and nutrient delivery.

3. development of novel pharmaceutical processors to create new dosage forms or solve long standing processing/formulation issues.

The research arena includes:

1. design of particulate drug delivery systems and molecular pharmaceutics in which the molecular details of pharmaceutical materials are elucidated and defined in relation to the need to predict their biological as well as physicochemical properties essential in design of drug delivery systems.

2. drug targeting for treatment of cancer (colorectal, skin, lung), diabetes and infection, via the invention and application of breakthrough pharmaceutical technology.

The research scope is mainly divided into four divisions:

1. Drug delivery system design.

2. Material sciences.

3. Technology invention.

4. Animal study.

Drug delivery system design

Research study directs at innovative design of multi-particulate drug delivery systems such as nanoparticles, microparticles and agglomerates. In addition, films for the application in transdermal and topical drug delivery are invented.

Material sciences


Research study directs at elucidation and analysis of structure-property relationships of pharmaceutical polymers and drugs. 

Technology invention


Research study directs at invention of novel pharmaceutical technology in relation to the need of drug targeting for treatment of medical illnesses such as diabetes and cancer.

Molecular biology and in vivo study

Research study directs to examine the functional properties of drug delivery systems, biological effects of polymers and drugs, as well as, drug targeting property of the intended dosage form.


PhD and MSc research project vacancies are available.  Enquiries: wongtinwui@uitm.edu.my



The research centre welcomes industry projects on product research, development and commercialization. The project focuses primarily on scientific basis of product formulation and performance. The activity of projects spans from academic study to upscaling of process and production.



  • PharmaTech charity program for homeless animals (starting 2010).
  • Recycle for charity for homeless animals (starting 2013).




Professor Dr Wong Tin Wui


Dr Nor Khaizan Anuar (Pharmacy)

Dr Heo Chong Chin (Medical)

Dr Mohd Shahezwan Abd. Wahab (Pharmacy)

Associate Professor Wang Seok Mui (Medical)



Idanawati Naharudin (Pharmacy)


Facilities & Expertise

Spray dryer.

Nanospray dryer.

Generation II nanospray dryer.

Extruder-spheronizer (mini and pilot scale).

Melt pelletizer (generation I, II and III).

Tabletting equipment.


Oven (hot air, vacuum, rotary, microwave).

Ball mill.

Fourier transform infrared spectrometer/imaging system.

 Differential scanning calorimeter.

Thermogravimetric analyser.

X-ray diffractometer.

Raman spectrometer.

Biochemical analyser.

Skin tester (transepidermal water loss, pH, moist etc).

 Franz diffusion cell.

Dissolution tester.

 UV-Vis spectrophotometer.

Atomic absorption spectrometer.

Microwave vector network analyser.

Zeta sizer.

 Laser diffraction particle sizer.

Mercury porosimeter.

Surface area and pore size analyser.

Elemental analyser.

 pH meter.



Microscope (compound, stereo, fluorescence).

Scanning electron microscope.

Transmission electron microscope.

Confocal electron microscope.

Total internal reflectance fluorescence microscope.

Tensile tester.

Microplate reader.

Cascade impactor.

High performance liquid chromatography etc.



Sustainable Development Goals International Innovation Awards, the final part of MTE2021 Awards Programme will take place in October 2021.   This inaugural event is the first in the region focused on recognizing innovations, initiatives, programmes and ideas which contribute to sustainability, eradicating poverty, improving well-being, protecting our planet, and building peace and prosperity. We invite Government Ministries, Agencies, Institutions, Local Government & Municipalities, Universities, Institutions of Higher Learning, Private Organisations, Social Enterprises, NGOs and Schools to submit entries by 6th Sept 2021.  


Enquiries: wongtinwui@uitm.edu.my